慢性心理应激对颈动脉粥样硬化狭窄程度及斑块性质影响

项目名称： 慢性心理应激对颈动脉粥样硬化狭窄程度及斑块性质影响

项目编号： No.31271097

项目类型： 面上项目

立项/批准年度： 2013

项目学科： 医药、卫生

项目作者： 龚涛

作者单位： 卫生部北京医院

项目金额： 80万元

中文摘要： 我国脑血管病是第一致残及致死疾病，其中缺血性脑血管病占80%-85%。目前导致缺血性脑血管病不能有效控制的重要原因之一是不能及时发现、动态监测及有效阻止动脉粥样硬化病变中狭窄及易损斑块地发生与进展。慢性心理应激是动脉粥样硬化重要的促发因素之一，但其对动脉粥样硬化狭窄及易损斑块的影响方式及程度还没有得到充分研究。本研究在建立无或有慢性心理应激的颈动脉粥样硬化狭窄动物模型的基础上，在不同时间段内检查血液激素水平、凝血状态、炎症因子、代谢产物等生物学指标，利用功能磁共振检查大脑神经内分泌功能区结构变化；利用血管造影检查颈动脉粥样硬化狭窄病变程度；利用高分辨率MRI及病理检测手段检查斑块性质。从而动态观察无或有慢性心理应激颈动脉粥样硬化狭窄程度及斑块性质的差异，分析慢性心理应激影响颈动脉粥样硬化狭窄程度及斑块性质的方式及程度，建立慢性心理应激的颈动脉粥样硬化狭窄动物模型及MRI评估斑块性质的方法。

中文关键词： 动脉粥样硬化；慢性应激；狭窄；斑块；机制

英文摘要： In China, cerebrovascular disease(CVD) ranks the first cause leading to disability and death and the ischemic CVD(ICVD) accounts for 80%-85% of all patients with CVD. Up to now, one of the important causes which we can not control effectively the ICVD is that we can not find out in time ,monitor dynamically, and prevent effectively the atherosclerotic stenosis and vulnerable plaque from occurring and progressing . The chronic psychologic stress(CPS) is one of the important promoting causes of atherosclerosis. But, the maneover and degree for it to accelerate stenosis and vulnerable plaque of astherosclerosis have been not researched clearly. In our study, on the basis of establishing the experimental carotid atherosclerotic stenosis(CASS) disorder of New Zealand rabbits without or with the CPS, during different hours, to detect biomarkers of the hormone level, coagulable state, inflammational factors , metabolin etc.in the blood of them , to detect the constructural change of functional region of neuro-endocrine with functional MRI, the stenotic degree of carotid atherosclerotic disorders with DSA, the characteristics of plaque with high-resolution, contrast-enhanced magnetic resonance imaging and histo-pathological examination. Then to observe the difference of carotid atherosclerotic stenotic degree and c

英文关键词： atherosclerosis；chronic stress；stenosis；plaque；pathogenesis