含硫醚键共聚物的分子设计、组装以及具有介孔核结构聚合物胶束的制备

项目名称： 含硫醚键共聚物的分子设计、组装以及具有介孔核结构聚合物胶束的制备

项目编号： No.51473079

项目类型： 面上项目

立项/批准年度： 2015

项目学科： 一般工业技术

项目作者： 赵汉英

作者单位： 南开大学

项目金额： 85万元

中文摘要： 功能化的聚合物胶束是指带有功能分子或由功能分子修饰的聚合物胶束。近年来功能性聚合物胶束在纳米技术以及生物医学领域得到广泛应用。本项目拟在合成连接点为硫醚键的多组分聚合物基础上制备核内具有介孔结构的聚合物胶束，并实现聚合物胶束的功能化。首先合成三种具有不同拓扑结构并在疏水聚合物链连接点上带有硫醚键的三臂星形聚合物、嵌段-接枝聚合物和梳-梳形聚合物。在合成的基础上，对聚合物在溶液中的自组装行为进行详细的研究。通过控制聚合物结构、组装条件等实现对胶束形态结构及尺寸的调控。加入三丁基磷后硫醚键断裂，经分离得到核内具有介孔结构的聚合物胶束。利用介孔壁上巯基基团与功能分子间的化学反应，制备一系列功能化的聚合物胶束。

中文关键词： 自组装；可控聚合；梳形聚合物；嵌段共聚物；星形聚合物

英文摘要： Polymer micelles with functional groups or functional molecules are called functional polymer micelles. Functional polymer micelles have found wide applications in nanotechnology and bio-medical science. In this proposal, synthesis of multicomponent polymers with disulfide bonds at junction points, and preparation and functionlization of polymeric micelles with mesoporous cores are proposed. Three types of polymers with different topological structures, including star polymers, block-graft polymers and comb-comb polymers, will be synthesized in this project. In the structures of the polymers, there are disulfide bonds at the junction points between two different hydrophobic chains. Self-assembly of the polymers in solutions will also be investigated. By controlling polymer structures and environmental conditions, the morphologies and sizes of the poymeric micelles can be controlled. After cleavage of the disulfide bonds by Bu3P, polymeric micelles with mesoporous cores are obtained. Chemical reactions between functional molecules and thiol groups on the walls of the pores, result in functional polymeric micelles.

英文关键词： self-assembly;controlled polymerizations;comb polymers;block cooplymers;star polymers