反向冲击加速度对颈动脉粥样硬化斑块影响的基础研究

项目名称： 反向冲击加速度对颈动脉粥样硬化斑块影响的基础研究

项目编号： No.31271004

项目类型： 面上项目

立项/批准年度： 2013

项目学科： 生物科学

项目作者： 张海钟

作者单位： 中国人民解放军总医院

项目金额： 80万元

中文摘要： 临床发现车祸碰撞后,一些颈动脉粥样硬化患者不仅有颅内血肿等出血性的病变，而且有急性的脑动脉梗塞等缺血性病变。我们根据这种特殊的现象，结合颈动脉粥样硬化导致脑梗塞的机制，提出车辆撞击时的反向冲击加速度导致斑块破裂脱落，继而随动脉走行后堵塞颅内小动脉导致脑缺血性病变（脑梗塞）的可能机制。本研究利用临床患者MRI数据，结合MIMICS和ANSYS有限元软件，建立流固耦合作用下的颈动脉分叉处三维模型并进行血流动力学分析。通过对上述损伤过程的数值模拟，探索反向冲击加速度导致斑块脱落的可能机理。本研究不仅可以建立单个病人的个体化模型，在此基础上进行血流数值模拟。还可以在大样本量的临床资料上测量粥样硬化颈动脉和斑块的弹性模量，为粥样硬化颈动脉和斑块的生物力学研究打下基础。

中文关键词： 颈动脉；粥样硬化斑块；反向冲击加速度；血流动力学；弹性模量

英文摘要： A three-dimensional (3D) MRI-based computational model with ?uid-structure interactions (FSI) is introduced to perform mechanical analysis and explore the effect of reversed impact acceleration on carotid artery atherosclerotic plaques which may be related to plaque rupture.3D reconstruction of hemodynamics model of human carotid artery were provided from MR images and computational mesh was generated using MIMICS. Both the artery wall and the plaque components were assumed to be hyperelastic,isotropic,incompressible and hemogeneous. The flow was assumed to be laminar,Newtonian,biscous, and incompressible.The fluid and structure models were solved by ANSYS, a well-tested finite element package.The elastic modulus of carotid artery with atherosclerosis and atherosclerotic plaques were measured to present a better FSI model.This work may represnts a step towards a better understanding of the conection between a reversed impact acceleration and plaque ruture.We are also trying to demonstrate the significance of hemodynamics in this process.

英文关键词： carotid artery；atheroma；reversed impact acceleration；hemodynamics；elastic modulus