扼住命运的咽喉！这种小鱼挽救重症了淋巴病男孩 | Nature 子刊论文精选

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扼住命运的咽喉！斑马鱼帮助挽救重症淋巴病男孩

论文标题：ARAF recurrent mutation causes central conducting lymphatic anomaly treatable with a MEK inhibitor

作者：Dong Li, Michael E. March, Alvaro Gutierrez-Uzquiza, Charlly Kao, Christoph Seiler, Erin Pinto, Leticia S. Matsuoka, Mark R. Battig, Elizabeth J. Bhoj, Tara L. Wenger, Lifeng Tian, Nora Robinson, Tiancheng Wang, Yichuan Liu, Brant M. Weinstein, Matthew Swift, Hyun Min Jung, Courtney N. Kaminski, Rosetta Chiavacci, Jonathan A. Perkins, Michael A. Levine, Patrick M. A. Sleiman, Patricia J. Hicks, Janet T. Strausbaugh, Jean B. Belasco, Yoav Dori, Hakon Hakonarson

期刊：Nature Medicine

发表时间：2019/07/01

一种口服细菌补充剂，解锁代谢综合征

论文标题：Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study

作者：Clara Depommier, Amandine Everard, Céline Druart, Hubert Plovier, Matthias Van Hul, Sara Vieira-Silva, Gwen Falony, Jeroen Raes, Dominique Maiter, Nathalie M. Delzenne, Marie de Barsy, Audrey Loumaye, Michel P. Hermans, Jean-Paul Thissen, Willem M. de Vos, Patrice D. Cani

期刊：Nature Medicine

发表时间：2019/07/01

十年坎坷！多疾病模型基因数据库拯救数千实验小鼠

论文标题：Transcriptional profiling unveils type I and II interferon networks in blood and tissues across diseases

作者：Akul Singhania, Christine M. Graham, Leona Gabryšová, Lúcia Moreira-Teixeira, Evangelos Stavropoulos, Jonathan M. Pitt, Probir Chakravarty, Annika Warnatsch, William J. Branchett, Laura Conejero, Jing-Wen Lin, Sophia Davidson, Mark S. Wilson, Gregory Bancroft, Jean Langhorne, Eva Frickel, Abdul K. Sesay, Simon L. Priestnall, Eleanor Herbert, Marianna Ioannou, Qian Wang, Ian R. Humphreys, Jonathan Dodd, Peter J. M. Openshaw, Katrin D. Mayer-Barber, Dragana Jankovic, Alan Sher, Clare M. Lloyd, Nicole Baldwin, Damien Chaussabel, Venizelos Papayannopoulos, Andreas Wack, Jacques F. Banchereau, Virginia M. Pascual, Anne O’Garra

期刊：Nature Communications

发表时间：2019/06/28

无需贵金属，铁催化剂即可实现环氧化物转化为伯醇

论文标题：Iron-catalysed regioselective hydrogenation of terminal epoxides to alcohols under mild conditions

作者：Weiping Liu, Wu Li, Anke Spannenberg, Kathrin Junge, Matthias Beller

期刊：Nature Catalysis

发表时间：2019/06/13

Nature 子刊再论基因编辑婴儿风险：CCR5 突变与寿命缩短有关

论文标题：CCR5-∆32 is deleterious in the homozygous state in humans

作者：Xinzhu Wei, Rasmus Nielsen

期刊：Nature Medicine

发表时间：2019/06/03

擒贼先擒王——代谢组学分析发现肿瘤干细胞的“软肋”

论文标题：Methionine is a metabolic dependency of tumor-initiating cells

作者：Zhenxun Wang, Lian Yee Yip, Jia Hui Jane Lee, Zhengwei Wu, Hui Yi Chew, Pooi Kiat William Chong, Chin Chye Teo, Heather Yin-Kuan Ang, Kai Lay Esther Peh, Ju Yuan, Siming Ma, Li Shi Kimberly Choo, Nurhidayah Basri, Xia Jiang, Qiang Yu, Axel M. Hillmer, Wan Teck Lim, Tony Kiat Hon Lim, Angela Takano, Eng Huat Tan, Daniel Shao Weng Tan, Ying Swan Ho, Bing Lim, Wai Leong Tam

期刊：Nature Medicine

发表时间：2019/05/06

让番茄更美味的基因被发现了

论文标题：The tomato pan-genome uncovers new genes and a rare allele regulating fruit flavor

作者：Lei Gao, Itay Gonda, Honghe Sun, Qiyue Ma, Kan Bao, Denise M. Tieman, Elizabeth A. Burzynski-Chang, Tara L. Fish, Kaitlin A. Stromberg, Gavin L. Sacks, Theodore W. Thannhauser, Majid R. Foolad, Maria Jose Diez, Jose Blanca, Joaquin Canizares, Yimin Xu, Esther van der Knaap, Sanwen Huang, Harry J. Klee, James J. Giovannoni, Zhangjun Fei

期刊：Nature Genetics

发表时间：2019/05/13

自发对称性破缺与嵌段共聚物自组装

论文标题：Emergent symmetries in block copolymer epitaxy

作者：Yi Ding, Karim R. Gadelrab, Katherine Mizrahi Rodriguez, Hejin Huang, Caroline A. Ross, Alfredo Alexander-Katz

期刊：Nature Communications

发表时间：2019/07/05

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