一种基于电阻抗技术的超早期脑水肿检测新方法的基础研究

项目名称： 一种基于电阻抗技术的超早期脑水肿检测新方法的基础研究

项目编号： No.51477176

项目类型： 面上项目

立项/批准年度： 2015

项目学科： 电工技术

项目作者： 付峰

作者单位： 中国人民解放军第四军医大学

项目金额： 96万元

中文摘要： 脑部疾病死亡位居人类死亡原因首位，其中多达80%的致死由脑水肿导致，脑水肿是所有颅脑疾病或创伤发生后都要经历的一个基本病理过程，会造成神经功能紊乱、神经细胞死亡、挫裂伤、颅内压升高、脑疝等严重的病理性损伤。因此脑水肿防治一直以来都是脑部疾病临床治疗的关键，对脑水肿的早期发现并及时干预能在很大程度上降低致残、致死风险。目前以CT、MR为代表的临床影像诊断技术对发现超早期脑水肿无能为力。本项目通过研究血管源性和细胞毒性这两类超早期脑水肿电阻抗特性及其变化规律，探索脑水肿超早期阶段电阻抗特性与组织形态、细胞内外液体环境、细胞超微结构变化之间关系，深入发掘电阻抗变化中包含的脑水肿组织微观形态、生物化学变化信息，分析脑水肿组织电阻抗特性中主要参数与脑组织微观形态、细胞内外液体环境参数的相关性，在电阻抗参数中提取与脑水肿最为敏感的指标，为超早期脑水肿的临床检测提供新的研究思路及技术方法。

中文关键词： 电阻抗；超早期脑水肿；血管源性脑水肿；细胞性脑水肿

英文摘要： Brain disease cause of death among the first human deaths , of which up to 80% resulting in death of brain edema , cerebral edema is a fundamental pathological process all brain diseases or traumatic experiences have occurred , the performance of the liquid within the brain tissue ingredient abnormal increase and reserving , causing neurological disorders, nerve cell death , serious injury pathological contusion, intracranial pressure, hernia , etc. Therefore, prevention of cerebral edema has been the key to the clinical treatment of patients with brain , brain edema on early detection and timely intervention can reduce disability in large part , the risk of death . Currently in CT, MR imaging , represented by clinical diagnostic techniques for early detection of cerebral edema powerless. By studying this project vasogenic cerebral edema and cerebral edema cytotoxic properties of two kinds of ultra- electrical impedance and its variation early brain edema , cerebral edema super early stages of exploring the electrical impedance characteristics and morphology , liquid environment inside and outside the cell , the cell ultrastructure the relationship between changes in brain edema tissue depth to explore morphology changes in electrical impedance contained , biochemical changes in information, analysis of brain edema tissue impedance characteristics and the main parameters of brain tissue morphology , intracellular and extracellular fluid environment correlation parameters for ultra-early detection of cerebral edema and real-time monitoring of clinical studies to provide new ideas and techniques.

英文关键词： electrical impedance;Ultra-early cerebral edema;vasogenic cerebral edema;cytotoxic brain edema