这种常用的食品添加剂，正在危害你的健康 | Science 子刊论文精选

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梅奥医学院孙杰组揭示 PD-1 在调控 CD8 组织定居记忆细胞介导的肺纤维化中起到重要作用

论文标题：PD-1hi CD8+ resident memory T cells balance immunity and fibrotic sequelae

作者：Zheng Wang, Shaohua Wang, Nick P. Goplen, Chaofan Li, In Su Cheon, Qigang Dai, Su Huang, Jinjun Shan, Chaoyu Ma, Zhenqing Ye, Min Xiang, Andrew H. Limper, Eva-Carmona Porquera, Jacob E. Kohlmeier, Mark H. Kaplan, Nu Zhang, Aaron J. Johnson, Robert Vassallo

期刊：Science Immunology

发表时间：2019/06/14

脂肪吃多也不用怕，让肠道细菌帮助减肥

论文标题：The gut microbiota regulates white adipose tissue inflammation and obesity via a family of microRNAs

作者：Anthony T. Virtue, Sam J. McCright, Jasmine M. Wright, Monica T. Jimenez, Walter K. Mowel, Jonathan J. Kotzin, Leonel Joannas, Megha G. Basavappa, Sean P. Spencer, Megan L. Clark, Stephen H. Eisennagel, Adam Williams, Maayan Levy, Sasikanth Manne, Sarah E. Henrickson, E. John Wherry, Christoph A. Thaiss, Eran Elinav

期刊：Science Translational Medicine

发表时间：2019/06/12

母乳喂养可为婴儿提供终身保护

论文标题：Pre-conception maternal helminth infection transfers via nursing long-lasting cellular immunity against helminths to offspring

作者：Matthew G. Darby, Alisha Chetty, Dunja Mrjden, Marion Rolot, Katherine Smith, Claire Mackowiak, Delphine Sedda, Donald Nyangahu, Heather Jaspan, Kai-Michael Toellner, Ari Waisman, Valerie Quesniaux, Bernhard Ryffel, Adam F. Cunningham, Benjamin G. Dewals, Frank Brombacher

期刊：Science Advances

发表时间：2019/05/01

借鉴阿尔茨海默症研究！发现更安全的白血病治疗方法

论文标题：Safe targeting of T cell acute lymphoblastic leukemia by pathology-specific NOTCH inhibition

作者：Roger A. Habets, Charles E. de Bock, Lutgarde Serneels, Inge Lodewijckx, Delphine Verbeke, David Nittner, Rajeshwar Narlawar, Sofie Demeyer, James Dooley, Adrian Liston, Tom Taghon, Jan Cools

期刊：Science Translational Medicine

发表时间：2019/05/29

改良基因疗法，科学家为病毒装上“别吃我”信号

论文标题：Phagocytosis-shielded lentiviral vectors improve liver gene therapy in nonhuman primates

作者：Michela Milani, Andrea Annoni, Federica Moalli, Tongyao Liu, Daniela Cesana, Andrea Calabria, Sara Bartolaccini, Mauro Biffi, Fabio Russo, Ilaria Visigalli, Andrea Raimondi, Susannah Patarroyo-White, Douglas Drager, Patrizia Cristofori, Eduard Ayuso, Eugenio Montini, Robert Peters, Matteo Iannacone, Alessio Cantore

期刊：Science Translational Medicine

发表时间：2019/05/22

新颖！这种 mRNA 有望带来新型免疫疗法

论文标题：A lipid-encapsulated mRNA encoding a potently neutralizing human monoclonal antibody protects against chikungunya infection

作者：Nurgun Kose, Julie M. Fox, Gopal Sapparapu, Robin Bombardi, Rashika N. Tennekoon, A. Dharshan de Silva, Sayda M. Elbashir, Matthew A. Theisen, Elisabeth Humphris-Narayanan, Giuseppe Ciaramella, Sunny Himansu, Michael S. Diamond

期刊：Science Immunology

发表时间：2019/05/17

明星抗癌药失效后，华人团队找到了治疗新思路

论文标题：Metabolic reprogramming toward oxidative phosphorylation identifies a therapeutic target for mantle cell lymphoma

作者：Liang Zhang, Yixin Yao, Shaojun Zhang, Yang Liu, Hui Guo, Makhdum Ahmed, Taylor Bell, Hui Zhang, Guangchun Han, Elizabeth Lorence, Maria Badillo, Shouhao Zhou, Yuting Sun, M. Emilia Di Francesco, Ningping Feng, Randy Haun, Renny Lan, Samuel G. Mackintosh, Xizeng Mao, Xingzhi Song, Jianhua Zhang, Lan V. Pham, Philip L. Lorenzi, Joseph Marszalek, Tim Heffernan, Giulio Draetta, Philip Jones, Andrew Futreal, Krystle Nomie, Linghua Wang

期刊：Science Translational Medicine

发表时间：2019/05/08

这种常用的食品添加剂，正在危害你的健康

论文标题：The short-chain fatty acid propionate increases glucagon and FABP4 production, impairing insulin action in mice and humans

作者：Amir Tirosh, Ediz S. Calay, Gurol Tuncman, Kathryn C. Claiborn, Karen E. Inouye, Kosei Eguchi, Michael Alcala, Moran Rathaus, Kenneth S. Hollander, Idit Ron, Rinat Livne, Yoriko Heianza, Lu Qi, Iris Shai, Rajesh Garg

期刊：Science Translational Medicine

发表时间：2019/04/24

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