Few health-related constructs or measures have received critical evaluation in terms of measurement equivalence, such as self-reported health survey data. Differential item functioning (DIF) analysis is crucial for evaluating measurement equivalence in self-reported health surveys, which are often hierarchical in structure. While traditional DIF methods rely on single-level models, multilevel models offer a more suitable alternative for analyzing such data. In this article, we highlight the advantages of multilevel modeling in DIF analysis and demonstrate how to apply the DIF framework to self-reported health survey data using multilevel models. For demonstration, we analyze DIF associated with population density on the probability to answer "Yes" to a survey question on depression and reveal that multilevel models achieve better fit and account for more variance compared to single-level models. This article is expected to increase awareness of the usefulness of multilevel modeling for DIF analysis and assist healthcare researchers and practitioners in improving the understanding of self-reported health survey data validity.
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